CBD steps forward
Although THC has grabbed a lot of the attention when it comes to marijuana’s therapeutic uses, CBD finds itself in the spotlight due to its lack of psychoactivity and numerous beneficial health effects.
CBD is well-tolerated
Chronic use and high doses of CBD have repeatedly shown to be easily tolerated by humans and mice, with no neurological, psychiatric, or clinical adverse effects. In one study, 60 mg/kg of CBD was given to mice three times per week for 12 weeks with no adverse effects.
Nevertheless, the study did point out that some side effects have been reported with the use of CBD, but these are in vitro or in animal studies. They include alterations of cell viability, lowered fertilization capacity, and inhibition of hepatic drug metabolism and drug transporters. More studies have to be conducted to see if these side effects also occur in humans.
Can CBD interact with other drugs?
CBD can interact with some drugs, including medications metabolized by enzymes belonging to the cytochrome P450 family. The P450 enzyme group is responsible for metabolizing many common medications, like ibuprofen, naproxen, acetaminophen, codeine, caffeine, Xanax, and Lipitor.
CBD may also inhibit the enzymes CYP2D6 and CYP2C9, which can potentially slow down the metabolization of certain drugs. In one human study, CBD was also found to interact with isozymes CYP3A4 and CYP2C19, resulting in an increase in bioavailability of the anti-epileptic drug clobazam, making it more effective at a lower dose and allowing patients to effectively manage seizures while reducing their dose of the anti-epileptic drug.
These findings suggest that considerations must be taken when CBD is administered alongside other drugs. The authors acknowledge that more research on CBD and its safety profile is paramount.
What’s next for CBD research?
More participants need to be included in future clinical trials; and that there needs to be more studies and research evaluating CBD’s effect on hormones.
So, while the study does confirm the previously held belief that CBD is very safe, even in high doses, there is still research to be done in order for CBD to realize its potential.