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Endocannabinoid
System

What is it?

Bottle of Meterra's CBD Gel Capsules

What is it?

The Endocannabinoid System (ECS) is a self-regulating system of cannabinoid receptors that are located throughout the body. The ECS is involved in communicating with nearly every system of the body including the central nervous system, immune system and organs. This vital system is focused on supporting balance or homestatsis in the body. CBD is one of the primary cannabinoids found in hemp.

These cannabinoid receptors play a pivotal role in physiological processes such as mood, memory and discomfort. There are two cannabinoid receptors - CB1 and CB2 that are located on cells throughout the body.

What are CB1 and CB2 receptors?

CB1 receptors are primarily located on nerve cells in the brain, spinal cord and central nervous system. They are very abundant in the cerebellum, basal ganglia, and hippocampus. CB1 receptors have been found to play a role in memory processing, motor regulation, discomfort sensation, mood, and sleep. CB2 receptors are primarily found on cells in the immune system and its associated structures. When activated, they stimulate a response that fights inflammation, which can reduce discomfort and minimize damage to tissues.

CBD
Receptors

Select and see

CB1 Receptors
1

Brain / CNS / Spinal Cord Cortigal Regions / Cerebellum / Brainstem (neocortex, pyriform cortex, hippocampus, amygdala)

2

Thyroid (endocrine gland)

3

Upper Airways (of mammals)

4

Liver (kupffer cells - macrophage immune cells, hepatocytes - liver cell, hepatic stellate cells - fat storage cell)

5

Adrenals / Basal Ganglia / Thalamus / Pituitary / Hypothalamus / Olfactory Bulb (endocrine gland, globus pallidus, substantia nigra pars, reticulata, endocrine-brain link)

6

Ovaries (gonads and endocrine gland)

7

Uterus (myometrium)

8

Prostate (epithelial and smooth muscle cells)

9

Testes (gonads and endocrine gland, leydig cells, sperm cells)

CB2 Receptors
1

Eye (Retinal pigment epithelial, RPE cells)

2

Stomach

3

Heart

4

Pancreas

5

Digestive Tract

6

Bone

Brain Receptors
1

Basal Ganglia (Movement)

2

Cerebral Cortex (Higher Cognitive Function)

3

Hypothalamus (Appetite)

4

Cerebellum (Movement)

5

Hippocampus (Learning, Memory, Stress)

6

Medulla (Nausea and vomiting, chemoreceptor)

7

Spinal Cord (Peripheral Sensation including discomfort)

CB1 Receptors
CB2 Receptors
Brain

How do these

Receptors
Work?

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Cannabinoids help coordinate and regulate how we feel and think by binding with the endocannabinoid system's CB1 and CB2 receptors. Cannabinoids are designed to link together with the cannabinoid receptors, like a key to a lock.

Linking activates the receiving neuron into action, triggering a set of events to pass along the message and carry out a variety of cellular responses needed for homeostasis and healthy functioning.