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Endocannabinoid
System

What is it?

Bottle of Meterra's CBD Gel Capsules

Discovered in the 20th Century, the endocannabinoid system is a biological system composed of endocannabinoids that are neurotransmitters that bind to cannabinoid receptors in the mammalian brain and body. CBD is one of the primary cannabinoids found in hemp.

These cannabinoid receptors play a pivotal role in physiological processes such as mood, memory and pain. There are two cannabinoid receptors - CB1 and CB2 that are located on cells throughout the body.

What are CB1 and CB2 receptors?

CB1 receptors are primarily located on nerve cells in the brain, spinal cord and central nervous system. They are very abundant in the cerebellum, basal ganglia, and hippocampus. The CB1 receptors have been found to play a role in memory processing, motor regulation, pain sensation, mood, and sleep. CB2 receptors are primarily found on cells in the immune system and its associated structures. When activated, they stimulate a response that fights inflammation, which can reduce pain and minimize damage to tissues.

Concentrations

CBD
Receptors

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CB1 Receptors
1

Brain / CNS / Spinal Cord Cortigal Regions / Cerebellum / Brainstem (neocortex, pyriform cortex, hippocampus, amygdala)

2

Thyroid endocrine gland

3

Upper Airways of mammals

4

Liver kupffer cells (macrophage immune cells), hepatocytes (liver cell), hepatic stellate cells (fat storage cell)

5

Adrenals / Basal Ganglia / Thalamus / Pituitary / Hypothalamus / Olfactory Bulb endocrine gland / Globus pallidus, substantia nigra pars, reticulata / (endocrine-brain link CB1)

6

Ovaries gonads and endocrine gland

7

Uterus myometrium

8

Prostate epithelial and smooth muscle cells

9

Testes gonads and endocrine gland CB1): Leydig cells; sperm cells

CB2 Receptors
1

Eye Retinal pigment epithelial / RPE cells

2

Stomach

3

Heart

4

Pancreas

5

Digestive Tract

6

Bone

Brain Receptors
1

Basal Ganglia Movement

2

Cerebral Cortex Higher Cognitive Function

3

Hypothalamus Appetite

4

Cerebellum Movement

5

Hippocampus Learning, Memory, Stress

6

Medulla Nausea and vomiting, chemoreceptor

7

Spinal Cord Peripheral Sensation including Pain

CB1 Receptors
CB2 Receptors
Brain

How do these

Receptors
Work?

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Cannabinoids help coordinate and regulate how we feel and think by binding with the endocannabinoid system's CB1 and CB2 receptors. Fitting like puzzle pieces, cannabinoids are designed to link together with the cannabinoid receptors.

Linking activates the receiving neuron into action, triggering a set of events to pass along the message and carry out a variety of cellular responses needed for homeostasis and healthy functioning.

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